In an unfunny, scattered sequel to their successful Up in Smoke, Cheech Marin and Tommy Chong reprise their roles as carefree men who do inhale. But this time around Cheech is out of a job and trying to dodge his bilious neighbor while chasing the lovely Donna (Evelyn Guerrero) with anything but honorable intentions. Meanwhile, Cheech's cousin Red (also Cheech Marin) and Chong go tooling around Hollywood in a luxury sports car looking for adventure.